Journal
COGNITIVE BRAIN RESEARCH
Volume 17, Issue 2, Pages 419-430Publisher
ELSEVIER
DOI: 10.1016/S0926-6410(03)00144-7
Keywords
response inhibition; fMRI; Go/No-go; supplementary motor area; doroslateral prefrontal cortex; working memory cerebellum
Funding
- NCRR NIH HHS [M01 RR00052, P41 RR15241] Funding Source: Medline
- NIMH NIH HHS [K01 MH01824] Funding Source: Medline
- NINDS NIH HHS [K08 NS02039] Funding Source: Medline
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Event-related fMRI was used to investigate the hypothesis that neural activity involved in response inhibition depends upon the nature of the response being inhibited. Two different Go/No-go tasks were compared-one with a high working memory load and one with low. The 'simple' Go/No-go task with low working memory load required subjects to push a button in response to green spaceships but not red spaceships. A 'counting' Go/No-go task (high working memory load) required subjects to respond to green spaceships as well as to those red spaceships preceded by an even number of green spaceships. In both tasks, stimuli were presented every 1.5 s with a 5:1 ratio of green-to-red spaceships. fMRI group data for each task were analyzed using random effects models to determine signal change patterns associated with Go events and No-go events (corrected Pless than or equal to0.05). For both tasks, Go responses were associated with signal change in the left primary sensorimotor cortex, supplementary motor area (SMA) proper, and anterior cerebellum (right>left). For the simple task, No-go events were associated with activation in the pre-SMA; the working memory-loaded 'counting' task elicited additional No-go activation in the right dorsolateral prefrontal cortex. The findings suggest that neural contributions to response inhibition may be task dependent; the pre-SMA appears necessary for inhibition of unwanted movements, while the dorsolateral prefrontal cortex is recruited for tasks involving increased working memory load. (C) 2003 Elsevier B.V. All rights reserved.
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