Journal
CHEMOSPHERE
Volume 52, Issue 2, Pages 455-461Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0045-6535(03)00191-7
Keywords
biohalogenation; secondary metabolite; transaldolase; aldehyde dehydrogenase
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Organofluorine compounds are rare in Nature, with only a handful known to be produced by some species of plant and two microorganisms. Consequently, the mechanism of enzymatic carbon-fluorine bond formation is poorly understood. The bacterium Streptomyces cattleya biosynthesises fluoroacetate and 4-fluorothreonine as secondary metabolites and is a convenient system to study the biosynthesis and enzymology of fluorometabolite production. Using stable-isotope labelled precursors it has been shown that there is a common intermediate in the biosynthesis of the fluorometabolites, which has recently been identified as fluoroacetaldehyde. Studies with cell-free extracts of S. cattleya have identified two enzymes, an aldehyde dehydrogenase and a threonine transaldolase, that are involved in the biotransformation of fluoroacetaldehyde to fluoroacetate and 4-fluorothreonine. (C) 2002 Elsevier Science Ltd. All rights reserved.
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