Journal
DEVELOPMENT
Volume 130, Issue 13, Pages 3053-3062Publisher
COMPANY BIOLOGISTS LTD
DOI: 10.1242/dev.00534
Keywords
eyes absent; hedgehog; Drosophila; retinal determination; cubitus interruptus; photoreceptor; morphogenetic furrow
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Funding
- NEI NIH HHS [EY02520, R01 EY11232-01] Funding Source: Medline
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Although Hedgehog (Hh) signaling is essential for morphogenesis of the Drosophild eye, its exact link to the network of tissue-specific genes that regulate retinal determination has remained elusive. In this report, we demonstrate that the retinal determination gene eyes absent (eya) is the crucial link between the Hedgehog signaling pathway and photoreceptor differentiation. Specifically, we show that the mechanism by which Hh signaling controls initiation of photoreceptor differentiation is to alleviate repression of eya and decapentaplegic (dpp) expression by the zinc-finger transcription factor Cubitus interruptus (Ci(rep)). Furthermore, our results suggest that stabilized, full length Ci (Ci(act)) plays little or no role in Drosophila eye development. Moreover, while the effects of Hh are primarily concentration dependent in other tissues, hh signaling in the eye acts as a binary switch to initiate retinal morphogenesis by inducing expression of the tissue-specific factor Eya.
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