4.4 Article

Yersinia pestis TonB:: Role in iron, heme, and hemoprotein utilization

Journal

INFECTION AND IMMUNITY
Volume 71, Issue 7, Pages 4159-4162

Publisher

AMER SOC MICROBIOLOGY
DOI: 10.1128/IAI.71.7.4159-4162.2003

Keywords

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Funding

  1. NIAID NIH HHS [R56 AI033481, R01 AI025098, AI33481, R01 AI033481, AI25098] Funding Source: Medline

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In Yersinia pestis, the siderophore-dependent yersiniabactin (Ybt) iron transport system and heme transport system (Hmu) have putative TonB-dependent outer membrane receptors. Here we demonstrate that hemin uptake and iron utilization from Ybt are TonB dependent. However, the Yfe iron and manganese transport system does not require TonB.

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