Journal
BIOSENSORS & BIOELECTRONICS
Volume 18, Issue 7, Pages 891-898Publisher
ELSEVIER ADVANCED TECHNOLOGY
DOI: 10.1016/S0956-5663(02)00216-6
Keywords
biosensors; continuous monitoring; glucose; microdialysis
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The performances and the stability of a novel subcutaneous glucose monitoring system have been evaluated. GlucoDay(R) (A. Menarini I.F.R. S.r.l, Florence Italy) is a portable instrument provided with a micro-pump and a biosensor coupled to a microdialysis system capable of recording the subcutaneous glucose level every 3 min. Long and short term stability of the biosensor are discussed and the results of some critical in vitro and in vivo (on rabbits) experiments are reported. A linear response up to 30 mM has been found for in vivo glucose concentration. The sensitivity referred to blood glucose is better than 0.1 mM and the zero current is typically below the equivalent of 0.1 mM. In the accuracy study a mean bias of 2.7 mg/dl and a correlation coefficient equal to 0.9697 have been found. At room temperature, an excellent membrane stability assures good performances up to 6 months from the first use. (C) 2002 Elsevier Science B.V. All rights reserved.
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