Journal
JOURNAL OF BACTERIOLOGY
Volume 185, Issue 14, Pages 4276-4279Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JB.185.14.4276-4279.2003
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Funding
- NIGMS NIH HHS [R01 GM034360] Funding Source: Medline
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The crystal structure of the ketolide telithromycin bound to the Deinococcus radiodurans large ribosomal subunit shows that telithromycin blocks the ribosomal exit tunnel and interacts with domains II and V of the 23S RNA. Comparisons to other clinically relevant macrolides provided structural insights into its enhanced activity against macrolide-resistant strains.
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