Journal
JOURNAL OF BIOMATERIALS APPLICATIONS
Volume 18, Issue 1, Pages 15-23Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1177/0885328203018001002
Keywords
biomaterial; chitosan; sciatic nerve; immunological study; humoral immune response; cellular immune response
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This study demonstrated that when the regeneration of the axotomized sciatic nerve is induced through tubulization with chitosan, this biomaterial does not induce immunostimulation or immunodepression in the dog. Canine females were distributed among three groups: an intact control group which was only isolated, an axotomized control group, and an axotomized group which was tubulized with 3% chitosan prostheses. In vitro culture and phagocytosis tests, as well as IgG and IgM serum concentrations, were determined in peripheral blood on days 0, 15, 30 and 60. The results showed that chitosan implants did not importantly affect the immune response.
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