Journal
TRENDS IN CELL BIOLOGY
Volume 13, Issue 7, Pages 340-343Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/S0962-8924(03)00126-0
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The centrosome consists of a pair of centrioles and a surrounding matrix of pericentriolar material that anchors microtubule nucleation sites and consequently determines the number and organization of microtubules in interphase and mitotic cells. Recent studies utilizing a functional genomics approach in the nematode worm Caenorhabditis elegans and sophisticated light and electron microscopy techniques provide new insight into how centrioles act as centrosomal organizers and use a centriolar structural element to dictate centrosome size by defining their capacity to recruit pericentriolar material.
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