Journal
ENVIRONMENTAL RESEARCH
Volume 92, Issue 3, Pages 191-196Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/S0013-9351(02)00061-0
Keywords
air pollution; micronuclei test; mutagenesis; mice; peripheral erythrocytes
Ask authors/readers for more resources
In this study, we explored the role of chronic exposure to urban air pollution in causing DNA damage (micronuclei frequency in peripheral erythrocytes) in rodents in vivo. Mice (n = 20) were exposed to the urban atmosphere of Sao Paulo for 120 days (February to June 1999) and compared to animals (n = 20) maintained in the countryside (Atibaia) for the same period. Daily levels of inhalable particles (PM10), CO, NO2, and SO2, were available for Sao Paulo. Occasional measurements of CO and O-3 were made in Atibaia, showing negligible levels of pollution in the area. The frequency of micronuclei (repeated-measures ANOVA) increased with aging, the highest values obtained for the 90th day of experiment (P < 0.001). The exposure to urban air pollution elicited a significant (P = 0.016) increase of micronuclei frequency, with no significant interaction with time of study. Associations (Spearman's correlation) between pollution levels of the week that precede blood sampling and micronuclei counts were observed in Sao Paulo. The associations between micronuclei counts and air pollution were particularly strong for pollutants associated with automotive emissions, such as CO (P = 0.037), NO2 (P < 0.001), and PM10 (P < 0.001). Our results support the concept that urban levels of air pollution may cause somatic mutations. (C) 2002 Elsevier Science (USA). All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available