Assessment of axonal degeneration in Alzheimer's disease with diffusion tensor MRI

Purpose. Alzheimer disease (AD) causes cortical degeneration with subsequent degenerative cahnges of the white matter. The aim of this study was to investigate the extent of white matter tissue damage of patients with Alzheimer's disease in comparison with healthy subjects using diffusion tensor MRI (DTI).The value of integrated parallel imaging techniques (iPAT) for reduction of image distortion was assessed. Material and methods. We studied 9 patients with mild AD and 10 age and gender matched healthy controls. DTI brain scans were obtained on a 1.5 tesla system (Siemens Mlagnetlom Soriata) using parallel imaging (iPAT) and an EPI diffusion sequence with TE/TR 71 ms/6000 ms. We used an 8-cement head coil and:a GRAPPA reconstruction algorithm with an acceleration factor of 2. From the tensor, the mean diffusity (D), the fractional anisotropy (FA), and the relative anisotropy (RA) of several white matter regions were determined. Results. FA was significantly lower (p <0,05) in the white matter of the genu of corpus callosum from patients with AD than in the corresponding regions from healthy controls. There was trend observed for slightly higher ADC valves in the AD group (p=0,06). No significant changes were observed in the regions of the splenium internal capsule, pericallosal areas, frontal, temp parietal, and occipital lobe. The images obtained with iPAT contained substantially less susceptibility artefacts and were less distorted than images acquired with non-parallel imaging technique. Coclusions. DTI is a method with potential to access early stages of white matter damage in vivo. The altered FA and ADC values in the genu of corpus callosum of patients with AD presumably reflect the microscopic white matter degeneration. Acquisition time can be reduced by iPAT methods with less image distortion from susceptibility artefacts resulting in more accurate calculation of the diffusion error.