Journal
MAGNETIC RESONANCE IN MEDICINE
Volume 50, Issue 1, Pages 19-23Publisher
WILEY
DOI: 10.1002/mrm.10499
Keywords
GSH; human; MEGA; LCModel
Funding
- NCRR NIH HHS [P41RR008079] Funding Source: Medline
- NINDS NIH HHS [R01NS038672] Funding Source: Medline
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The concentration of reduced glutathione (GSH), an antioxidant, may be altered in various brain diseases. MEGA-PRESS was used to edit for the H-1 NMR signal from GSH in the occipital lobe of 12 normal humans. In all studies, GSH was clearly detected with a spectral pattern consistent with spectra acquired from a phantom containing GSH. Retention of singlet resonances in the subspectra, a key advantage of this difference-editing technique, provided an unambiguous reference for the offset and phase of the edited signal. Linear combination model (LCModel) analysis provided an unbiased means for quantifying signal contribution from edited metabolites. GSH concentration was estimated from the in vivo spectra as 1.3 +/- 0.2 mumol/g (mean +/- SD, n = 12). Magn Reson Med 50:19-23,2003. (C) 2003 Wiley-Liss, Inc.
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