Journal
ARCHIVES OF VIROLOGY
Volume 159, Issue 9, Pages 2497-2502Publisher
SPRINGER WIEN
DOI: 10.1007/s00705-014-2067-6
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Funding
- National Infectious Disease Surveillance Program of the Ministry of Science and Technology of the People's Republic of China [2012ZX10004201-003, 2013ZX10004202]
- National Science and Technology Major Project for Creation of Major New Drugs [2013ZX09304101-006]
- HFMD Surveillance Program of Qingdao Municipal Science and Technology Bureau [08-2-1-1-nsh]
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To characterize the genetic properties of coxsackievirus A12 (CVA12) strains isolated from hand, foot and mouth disease (HFMD) patients in Qingdao during 2008-2011, the complete genome and VP1 coding region were sequenced and analyzed. Phylogenetic analysis showed that all strains from China clustered into three different branches, suggesting multiple lineages of CVA12 co-circulating in Asia. Sequence analysis indicated a monophyletic group only when the P1 region was examined, indicating possible recombination between CVA12 and other HEV-A serotypes. The emergence of CVA12 involved in an HFMD outbreak in China is a public-health issue.
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