Journal
ARCHIVES OF VIROLOGY
Volume 158, Issue 12, Pages 2577-2581Publisher
SPRINGER WIEN
DOI: 10.1007/s00705-013-1754-z
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Funding
- Hungarian Ministry of Health
- Office of the Chief Medical Officer, Hungary
- FLUSECURE
- FASTVAC consortia
- Health Programme of the European Union
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Chinese painted quails immunized with a single dose (6 mu g HA) of inactivated H5N1 (clade 1) influenza vaccine NIBRG-14 and challenged with 100 LD50 of the heterologous A/Swan/Nagybaracska/01/06(H5N1) (clade 2.2) strain were protected, whereas unvaccinated quails died after challenge. No viral antigens or RNA were detected in cloacal swabs from immunized animals. Sera obtained post-immunization gave low titres in serological assays against the vaccine and the challenge viruses. Our results demonstrate the protective efficacy of the NIBRG-14 strain against the challenge virus and the usefulness of these small birds in protection studies of influenza vaccines.
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