Journal
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
Volume 51, Issue 7, Pages 985-990Publisher
BLACKWELL PUBLISHING INC
DOI: 10.1046/j.1365-2389.2003.51312.x
Keywords
exercise; hormone replacement therapy; frailty; elderly women
Categories
Funding
- NCRR NIH HHS [RR00036, K23 RR16191] Funding Source: Medline
- NIA NIH HHS [P60 AG013629, AG13629] Funding Source: Medline
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OBJECTIVES: To determine whether exercise training added to ongoing hormone replacement therapy (HRT) increases bone mineral density (BMD) in physically frail elderly women. DESIGN: Prospective controlled trial. SETTING: University-based research center. PARTICIPANTS: Twenty-eight women on HRT, aged 75 and older with physical frailty. INTERVENTIONS: Participants were assigned to 9 months of supervised (EXER) or home (HOME) exercise. The EXER program started with physical therapy and gradually incorporated resistance and endurance training. The HOME program consisted of flexibility exercises. MEASUREMENTS: Changes in BMD and body composition. RESULTS: There were larger increases in lumbar spine BMD in response to EXER than with HOME (3.5% vs 1.5%, P = .048), with a trend for larger increases in total body BMD (1.5% vs 0.2%, P = .058). There were no significant between-group differences in hip BMD. The EXER group had decreases in weight (-2.2 +/- 0.3 kg, P = .010) and fat mass (-2.7 +/- 0.4 kg, P = .018) and increases in muscle strength (9-30%, P < .05). CONCLUSION: In physically frail elderly women on HRT, relatively vigorous exercise training significantly increased lumbar spine BMD. The improved BMD and strength in response to exercise could reduce fracture risk in frail women already on HRT.
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