Journal
ARCHIVES OF VIROLOGY
Volume 159, Issue 6, Pages 1453-1457Publisher
SPRINGER WIEN
DOI: 10.1007/s00705-013-1947-5
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Funding
- Fundacao Amparo a Pesquisa do Estado de Sao Paulo [2010/52465-9, 2011/50845-1]
- CNPq (Brazilian Council for Research)
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In this study, we investigated turkey reovirus (TReoV) in tissue samples from young birds, aged 15 days. RT-PCR for TReoV detected 3.3 % positive samples and TReoV was successfully isolated in Vero cells. Histological analysis of positive bursa of Fabricius (BF) revealed atrophied follicles and lymphocyte depletion. The number of CD8+, CD4+ and IgM+ cells was lower in infected BF. Phylogenetic analysis based on S3 gene showed that the Brazilian TReoV isolates clustered in a single group with 98-100 % similarity to TReoV strains circulating in the United States. This is the first indication that TReoV infection may be a contributing factor to immunosuppression in young birds.
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