Journal
ARCHIVES OF VIROLOGY
Volume 157, Issue 11, Pages 2219-2222Publisher
SPRINGER WIEN
DOI: 10.1007/s00705-012-1396-6
Keywords
Hand-foot-mouth disease; enterovirus 71; co-detection
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Funding
- National Nature and Science Foundation of the People's Republic of China [30872150]
- Basic Research Expenditures of CAIQ [2010JK011, 2012JK037]
- Military Logistic Project [BWS11C073]
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It still needs to be elucidated whether co-detection of EV71 with other intestinal tract viruses plays a role in the pathogenesis of severe hand-foot-mouth disease (HFMD). A total of 680 stool specimens collected from clinically diagnosed mild and severe-HFMD patients were tested for EV71, CA16, norovirus, bocavirus and rotavirus. The results showed that EV71 was significantly associated with severe-HFMD patients. Co-detection of EV71 with norovirus and rotavirus was also significantly associated with severe-HFMD patients: The OR (95 % CI) value was 6.466 (2.735, 15.283) and 7.561 (3.560, 16.057), p < 0.001, respectively. Co-detection of EV71 with rotavirus or norovirus is probably associated with severe HFMD.
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