Journal
ARCHIVES OF VIROLOGY
Volume 157, Issue 12, Pages 2397-2403Publisher
SPRINGER WIEN
DOI: 10.1007/s00705-012-1436-2
Keywords
rabies virus; Chinese ferret badger; cell-culture-adapted virus; vaccine
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Funding
- China National 863 Program [2011AA10A212]
- Special Fund for Agro-Scientific Research in the Public Interest [201203056]
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Rabies virus strain JX08-45CC was derived from a Chinese isolate (JX08-45) by serial passage in the BHK-21 cell line, reaching a titer of 10(8) TCID50/mL. JX08-45CC produced rabies in adult mice but was nonpathogenic in dogs after intramuscular injection. A comparison of the entire genomes of JX08-45 and JX08-45CC led to the identification of 17 nucleotide substitutions, resulting in seven amino acid changes in the mature G and L proteins. The immunogenicity of beta-propiolactone-inactivated JX08-45CC was similar to the immunogenicity of the live vaccine strains widely used in China. The inactivated vaccine induced antibody responses for more than 6 months and provided full protection from an intramuscular challenge in dogs. JX08-45CC has excellent potential for development as an inactivated vaccine for dogs in China.
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