Journal
ARCHIVES OF VIROLOGY
Volume 157, Issue 1, Pages 121-127Publisher
SPRINGER WIEN
DOI: 10.1007/s00705-011-1115-8
Keywords
Arenavirus; Filovirus; Lassa virus; Ebola virus; Kinase inhibitors
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Funding
- Battelle Health and Life Sciences Independent Research and Development Program
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Arenaviruses and filoviruses are capable of causing hemorrhagic fever syndrome in humans. Limited therapeutic and/or prophylactic options are available for humans suffering from viral hemorrhagic fever. In this report, we demonstrate that pre-treatment of host cells with the kinase inhibitors genistein and tyrphostin AG1478 leads to inhibition of infection or transduction in cells infected with Ebola virus, Marburg virus, and Lassa virus. In all, the results demonstrate that a kinase inhibitor cocktail consisting of genistein and tyrphostin AG1478 is a broad-spectrum antiviral that may be used as a therapeutic or prophylactic against arenavirus and filovirus hemorrhagic fever.
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