Journal
ARCHIVES OF VIROLOGY
Volume 156, Issue 10, Pages 1737-1747Publisher
SPRINGER WIEN
DOI: 10.1007/s00705-011-1043-7
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Funding
- Alabama Agricultural Experiment Station Foundation
- Auburn University
- Upchurch Fund for Excellence
- National Science Foundation [0091853]
- NSF-EPS [0447675]
- NIH [P41 RR-01081]
- EPSCoR
- Office Of The Director [0447675] Funding Source: National Science Foundation
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Foot-and-mouth disease virus (FMDV) uses an internal ribosome entry site (IRES), a highly structured segment of its genomic RNA, to hijack the translational apparatus of an infected host. Computational analysis of 162 type II picornavirus IRES RNA sequences yielded secondary structures that included only base pairs supported by comparative or experimental evidence. The deduced helical sections provided the foundation for a hypothetical three-dimensional model of FMDV IRES RNA. The model was further constrained by incorporation of data derived from chemical modification and enzymatic probing of IRES RNAs as well as high-resolution information about IRES RNA-bound proteins.
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