Journal
JOURNAL OF ETHNOPHARMACOLOGY
Volume 87, Issue 1, Pages 27-34Publisher
ELSEVIER SCI IRELAND LTD
DOI: 10.1016/S0378-8741(03)00103-X
Keywords
anticonvulsant; Cyperus articulatus; spontaneous epileptiform discharges; water extract
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Cyperus articulatus L. (Cyperaceae) is a plant commonly used in traditional medicine in Africa and Latin America to treat many diseases. The water extract from rhizomes of Cyperus articulatus concentration-dependently reduced spontaneous epileptiform discharges and NMDA-induced depolarisations in the rat cortical wedge preparation at concentrations at which AMPA-induced depolarisations are not affected. The two antiepileptic compounds, valproate and ethosuximide, possessed effect neither on epileptiform discharges nor on AMPA- and NMDA-induced depolarisations. Phenobarbital, pentobarbital and phenythoin inhibited both AMPA- and NMDA-induced depolarisations and spontaneous epileptiform discharges. The effects of Cyperus articulatus were very close to the effect of D-CPPene: D-CPPene also inhibited spontaneous epileptiform discharges and antagonised NMDA- but not AMPA-induced depolarisations. The extract of Cyperus articulatus could contain components acting as NMDA antagonists. (C) 2003 Elsevier Science Ireland Ltd. All rights reserved.
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