Journal
FEBS LETTERS
Volume 546, Issue 1, Pages 65-72Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0014-5793(03)00453-8
Keywords
G protein-coupled receptor; PSD95-disc large-zona occludens domain-containing protein; Ena/VASP homology domain-containing protein; scaffolding; targeting; signaling
Ask authors/readers for more resources
All cell types express a great variety of G protein-coupled receptors (GPCRs) that are coupled to only a limited set of G proteins. This disposition favors cross-talk between transduction pathways. However, GPCRs are organized into functional units. They promote specificity and thus avoid unsuitable cross-talk. New methodologies (mostly yeast two-hybrid screens and proteomics) have been used to discover more than 50 GPCR-associated proteins that are involved in building these units. In addition, these protein networks participate in the trafficking, targeting, signaling, fine-tuning and allosteric regulation of GPCRs. To date, proteins that interact with the GPCR C-terminus are the most abundant and are the focus of this review. (C) 2003 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available