Journal
VACCINE
Volume 21, Issue 23, Pages 3179-3185Publisher
ELSEVIER SCI LTD
DOI: 10.1016/S0264-410X(03)00232-9
Keywords
recombinant hepatitis B vaccine; two-doses
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Healthy subjects (15-50 years old) were randomised to receive, intramuscularly, 10 or 20 mug of a yeast-derived recombinant hepatitis B vaccine (Heberbiovac HB) on a two-dose (0-1) schedule. Anti-hepatitis B surface antigen antibodies (HBsAb) were determined at 2, 3 and 6 months. Twenty micrograms immunisation yielded 96.3% seroprotection (HBsAb >10 IU/l) at t = 3, which persisted to 97.2% at t = 6. The 10 mug group resulted in 87.4% seroprotection at t = 3 and 81% at t = 6, but reached >95% among subjects <21 years old, both at t = 3 and 6. It is concluded that the vaccine used is highly immunogenic and the two-dose 20 mug immunisation can be used in all age groups and 10 mug in subjects up to 20 years. These schedules can result in significantly better compliance and cost-effectiveness of the vaccination programs. (C) 2003 Elsevier Science Ltd. All rights reserved.
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