Journal
TETRAHEDRON-ASYMMETRY
Volume 14, Issue 13, Pages 1837-1845Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0957-4166(03)00278-7
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The highly stereoselective synthesis of (1S,2S)-2-amino-1-hydroxyalkylphosphonic acids was achieved by addition of dimethyl phosphite to N-protected aminoaldehydes. Relative configuration and solution conformations of (1S,2S)-2-amino-lhydroxy-alkylphosphonic acids (in D2O) and their dimethyl esters (in CDCl3 and CD3OD) were established by means of NMR basing on the dependence between observed values of coupling constants ((3)J(HH), (3)J(PC), (3)J(HP)) and corresponding dihedral angles. Potentiometric and spectroscopic methods were used for the evaluation of the structure of the complexes of (1S,2S)-2-amino-lhydroxy-alkylphosphonic acids with Zn(II) and Cu(II) ions in aqueous solutions. (C) 2003 Elsevier Science Ltd. All rights reserved.
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