Journal
SCIENCE
Volume 301, Issue 5629, Pages 71-76Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1084337
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Funding
- NIGMS NIH HHS [R01 GM63803, R01 GM063803] Funding Source: Medline
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The sifting and winnowing of DNA sequence that occur during evolution cause nonfunctional sequences to diverge, leaving phylogenetic footprints of functional sequence elements in comparisons of genome sequences. We searched for such footprints among the genome sequences of six Saccharomyces species and identified potentially functional sequences. Comparison of these sequences allowed us to revise the catalog of yeast genes and identify sequence motifs that may be targets of transcriptional regulatory proteins. Some of these conserved sequence motifs reside upstream of genes with similar functional annotations or similar expression patterns or those bound by the same transcription factor and are thus good candidates for functional regulatory sequences.
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