Journal
JOURNAL OF THEORETICAL BIOLOGY
Volume 223, Issue 1, Pages 45-53Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/S0022-5193(03)00071-7
Keywords
networks; centrality; resource placement; protein interactions; metabolic networks
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The central vertices in complex networks are of particular interest because they might play the role of organizational hubs. Here, we consider three different geometric centrality measures, excentricity, status, and centroid value, that were originally used in the context of resource placement problems. We show that these quantities lead to useful descriptions of the centers of biological networks which often, but not always, correlate with a purely local notion of centrality such as the vertex degree. We introduce the notion of local centers as local optima of a centrality value landscape. on a network and discuss briefly their role. (C) 2003 Elsevier Science Ltd. All rights reserved.
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