Journal
ARCHIVES OF VIROLOGY
Volume 153, Issue 9, Pages 1777-1781Publisher
SPRINGER WIEN
DOI: 10.1007/s00705-008-0183-x
Keywords
-
Categories
Funding
- National Natural Science Foundation of China [30471552, 30640065, 30671853]
- Beijing Natural Science Foundation [5082004]
Ask authors/readers for more resources
The present study investigated the effect of microtubules (MTs) and vimentin during dengue virus serotype 2 (DV2) infection. Immunostaining showed that DV2 infection induced MT and vimentin reorganization. Colocalization of DV2 antigens with MTs or vimentin were often observed in ECV304 cells. MT-disrupting agents could enhance DV2 release but did not affect other steps of virus replication. In contrast, disruption of vimentin inhibited DV2 infection. Our results suggest that an MT-dependent mechanism may not be necessary for DV2 infection, and MT disruption may promote DV2 release. However, vimentin is required for DV2 infection.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available