Journal
JOURNAL OF MOLECULAR BIOLOGY
Volume 330, Issue 3, Pages 571-576Publisher
ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD
DOI: 10.1016/S0022-2836(03)00470-4
Keywords
PWWP domains; protein; molecule
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The PWWP domain is a ubiquitous eukaryotic protein module characterised by-a. region of sequence similarity of approximately 80 amino acids containing a highly conserved PWWP motif. It is frequently found in proteins associated with chromatin. We have determined the structure of a PWWP domain from the S. pombe protein SPBC215.07c using NMR spectroscopy. The structure is composed of a five stranded beta barrel followed by two alpha helices. Comparison to the recently reported structure of a homologous domain from the mammalian DNA methyltransferase Dnmt3b reveals substantial differences both in the C-terminal helical region and in the PWWP motif. (C) 2003 Published by Elsevier Science Ltd.
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