4.7 Article

Benzannulation of 3-substituted pyrroles to indoles

Journal

JOURNAL OF ORGANIC CHEMISTRY
Volume 68, Issue 14, Pages 5728-5730

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/jo026853m

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In a new general indole synthesis, the anion derived from benzotriazolyl derivative 5b underwent regioselective 1,4-addition to various alpha,beta-unsaturated ketones; subsequent acid-catalyzed cyclization formed the corresponding indoles 1a-f.

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