A new N,P-ligand with achiral gem-dimethyloxazoline for palladium(II)-catalyzed cyclization of 1,6-enynes:: Transition state probe for the NIC trans mode in mizoroki-heck-type C-C bond formation

A highly effective Cl-symmetric gem-dimethyl N,P-ligand has been developed for enantioselective palladium(II)-catalyzed carbocyclization of 1,6-enynes, in which the N/C trans mode is established for the first time in the Mizoroki-Heck-type transition state by virtue of the Cl-symmetric N,P-ligand. ((C) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003).