Journal
ARCHIVES OF TOXICOLOGY
Volume 92, Issue 11, Pages 3277-3289Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s00204-018-2305-x
Keywords
Apoptosis; Autophagy; Fluoride; IL-17; Liver
Categories
Funding
- National Natural Science Foundation of China [31672623, 31372497]
- Veterinary Environmental Lab (Shanxi Key Lab)
Ask authors/readers for more resources
Previous studies have reported that excessive fluoride exposure induced liver damage. However, the underlying mechanism of fluoride-induced hepatic toxicity is still unclear. Hence, this study was aimed to evaluate the fluoride-induced apoptosis, autophagy, and IL-17 signaling pathway-related genes to explore the possible mechanisms of NaF-induced liver injury in mice. For this, 48 male mice were allotted randomly to four groups, treated with deionized water, 25, 50, 100mg/L NaF for 150days continuously. Our results suggested that treatment with NaF decreased the PAS staining-positive area, with a concomitant increase in liver score, and serum ALT and AST levels which indicated that NaF induced the liver injury. In addition, the qRT-PCR, immunohistochemistry, and western blotting results indicated that NaF exposure activated IL-17 signaling, apoptosis, and autophagy pathways. In summary, these results suggested that NaF induced apoptosis and autophagy in liver by activating the IL-17 signaling pathway, eventually leading to impaired liver function.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available