Journal
JOURNAL OF THE NEUROLOGICAL SCIENCES
Volume 211, Issue 1-2, Pages 29-35Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0022-510X(03)00037-6
Keywords
Lewy body; dementia with Lewy bodies; alpha-synuclein; axonal transport blockage; axonal transport substances
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We investigated 10 dementia with Lewy bodies (DLB) brains showing various degrees of Lewy pathology using alpha-synuclein-immunohistochemistry, and morphologically divided cortical Lewy bodies (LB) into six developmental stages. Further, we demonstrated the ultrastructure of each stage of cortical LB using alpha-synuclein-immunoelectron microscopy. In the initial stage, alpha-synuclein accumulated in part of the neuronal cytoplasm without filamentous components, then formed LB and LB-related neurites composed of granulo-filamentous components. Finally, LB degraded to extracellular LB composed of loose filamentous components with involved astroglial processes. In addition, we immunohistochemically investigated the accumulation of axonal transported substances in cortical LB, and showed that APP, chromogranin-A. synphilin-1 and synaptophysin accumulated in cortical LB from stages 1, 2, 3 and 4, respectively. These findings suggest that chronic axonal transport blockage is implicated in the development of cortical LB in DLB brains. (C) 2003 Elsevier Science B.V All rights reserved.
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