Journal
TOXICOLOGY
Volume 189, Issue 1-2, Pages 55-61Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/S0300-483X(03)00152-5
Keywords
mongolian gerbil; SHRSP; delayed neuronal death; antioxidant nutrients
Categories
Ask authors/readers for more resources
Cerebral ischemia and recirculation cause delayed neuronal death in rodents, such as Mongolian gerbils and stroke-prone spontaneously hypertensive rats (SHRSP), which were used as an experimental stroke model. It was documented that an enhanced nitric oxide production, the occurrence of apoptosis, and an attenuated redox regulatory system contribute to the development of delayed neuronal death. Many studies have suggested the beneficial antioxidant effects of antioxidant nutrients such as vitamin E, green tea extract, ginkgo biloba extract, resveratrol and niacin in cerebral ischemia and recirculation brain injury. These results are important in light of an attenuation of the deleterious consequences of oxidative stress in ischemia and recirculation injury. (C) 2003 Elsevier Science Ireland Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available