Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 7, Issue 39, Pages 21727-21734Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsami.5b04427
Keywords
surface plasmon resonance; graphene; graphene oxide; sensor chips; sensing interface
Funding
- Ministry of Education and Science of the Russian Federation [16.19.2014/K, CCU MIPT RFMEFI59414 x 0009]
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The development of sensing interfaces can significantly improve the performance of biological sensors. Graphene oxide provides a remarkable immobilization platform for surface plasmon resonance (SPR) biosensors due to its excellent optical and biochemical properties. Here, we describe a novel sensor chip for SPR biosensors based on graphene-oxide linking layers. The biosensing assay model was based on a graphene oxide film containing streptavidin. The proposed sensor chip has three times higher sensitivity than the carboxymethylated dextran surface of a commercial sensor chip. Moreover, the demonstrated sensor chips are bioselective with more than 25 times reduced binding for nonspecific interaction and can be used multiple times. We consider the results presented here of importance for any future applications of highly sensitive SPR biosensing.
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