Journal
ARCHIVES OF TOXICOLOGY
Volume 89, Issue 10, Pages 1759-1769Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s00204-014-1325-4
Keywords
Iron oxide nanoparticles; Human blood cells; Inflammation; Cytokines; Interleukins
Categories
Funding
- Fundacao para a Ciencia e Tecnologia (FCT) [SFRH/BD/72856/2010]
- Marisa Freitas [SFRH/BPD/76909/2011]
- FSE
- national funds of MCTES
- Reitoria da Universidade do Porto
- Santander Totta for Projectos IJUP
- Fundação para a Ciência e a Tecnologia [SFRH/BD/72856/2010] Funding Source: FCT
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Iron oxide nanoparticles (ION) can have a wide scope of applications in biomedicine, namely in magnetic resonance imaging, tissue repair, drug delivery, hyperthermia, transfection, tissue soldering, and as antimicrobial agents. The safety of these nanoparticles, however, is not completely established, namely concerning their effect on immune system and inflammatory pathways. The aim of this study was to evaluate the in vitro effect of polyacrylic acid (PAA)-coated ION and non-coated ION on the production of six cytokines [interleukin 1 beta (IL-1 beta), tumor necrosis factor alpha (TNF-alpha), interleukin 6 (IL-6), interleukin 8 (IL-8), interferon gamma (IFN-gamma) and interleukin 10 (IL-10)] by human peripheral blood cells, and to determine the inflammatory pathways involved in this production. The obtained results showed that PAA-coated and non-coated ION were able to induce all the tested cytokines and that activation of transforming growth factor beta (TGF-beta)-activated kinase (TAK1), p38 mitogen-activated protein kinases (p38 MAPK) and c-Jun N-terminal kinases (JNK) were involved in this effect.
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