Chemical modification of cellulose membranes with sulfo ammonium zwitterionic vinyl monomer to improve hemocompatibility

Platelets from human plasma adhered on the cellulose membranes grafted with N,N-dimethyl-N-methacryloxyethyl-N-(3-sulfopropyl) ammonium (DMMSA) was studied. DMMSA was directly graft-polymerized onto the cellulose membranes using ceric ammonium nitrate (CAN) as initiator. Surface analysis of the grafted membranes by ATR-FTIR and ESCA confirmed that DMMSA was successfully grafted onto the SPEU membrane surface. The amount of PDMMSA grafted onto cellulose membranes increased with increasing the feed monomer concentration. The platelet resistant property of the grafted membranes was evaluated by a platelet-rich plasma adhesion study and scanning electron microscopy, using original cellulose membranes as the control. The results showed that platelet-adhesive resistance of the modified cellulose membrane has been greatly improved. This kind of new biomaterials grafted with sulfo ammonium zwitterionic vinyl monomers might have potential for biomedical applications. (C) 2003 Elsevier Science B.V. All rights reserved.