Journal
NUCLEIC ACIDS RESEARCH
Volume 31, Issue 14, Pages 4201-4210Publisher
OXFORD UNIV PRESS
DOI: 10.1093/nar/gkg469
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Funding
- NIAID NIH HHS [R01 AI40599, U01 AI040599, R01 AI053667] Funding Source: Medline
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Leishmania parasites (order Kinetoplastida, family Trypanosomatidae) cause a spectrum of human diseases ranging from asymptomatic to lethal. The similar to33.6 Mb genome is distributed among 36 chromosome pairs that range in size from similar to0.3 to 2.8 Mb. The complete nucleotide sequence of Leishmania major Friedlin chromosome 1 revealed 79 protein-coding genes organized into two divergent polycistronic gene clusters with the mRNAs transcribed towards the telomeres. We report here the complete nucleotide sequence of chromosome 3 (384 518 bp) and an analysis revealing 95 putative protein-coding ORFs. The ORFs are primarily organized into two large convergent polycistronic gene clusters (i.e. transcribed from the telomeres). In addition, a single gene at the left end is transcribed divergently towards the telomere, and a tRNA gene separates the two convergent gene clusters. Numerous genes have been identified, including those for metabolic enzymes, kinases, transporters, ribosomal proteins, spliceosome components, helicases, an RNA-binding protein and a DNA primase subunit.
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