Journal
NEUROSCIENCE LETTERS
Volume 345, Issue 2, Pages 126-130Publisher
ELSEVIER SCI IRELAND LTD
DOI: 10.1016/S0304-3940(03)00469-5
Keywords
glutamate receptor; (+/-)-alpha-Amino-3-hydroxy-5-methylisoxazole-4-propionic acid; kainate; spinal cord; white matter
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Funding
- NINDS NIH HHS [NS 41056] Funding Source: Medline
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Our recent study on ionotropic (+/-)-alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA)/kainate (KA) type glutamate receptors in mouse spinal cord revealed differences compared with reports on other species. Inconsistencies in such findings may reflect real inter-species variability or differences in technique. To date, no comprehensive study has directly addressed this issue. Thus, we compared, side-by-side, AMPA/KA receptor expression in mouse and rat spinal cord white matter. Tissue from both species underwent identical processing, using the same reagents, immunofluorescence protocol, and confocal microscopy. Both mouse and rat white matter astrocytes displayed similar AMPA/KA subunit profiles (both species, GluR2/3 and GluR6/7). However, substantial inter-species differences were found for oligodendrocytes (KA2 in mouse; GluR4 and GluR2/3 in rat). Knowledge of such differences can aid in understanding the effects of variably selective AMPA/KA antagonists on glutamate excitotoxicity in white matter. (C) 2003 Published by Elsevier Science Ireland Ltd.
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