Journal
SCIENCE
Volume 301, Issue 5631, Pages 379-383Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1082795
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Funding
- NHLBI NIH HHS [HL 64148] Funding Source: Medline
- NIDDK NIH HHS [5T3DK07328] Funding Source: Medline
- NIMH NIH HHS [4R37 MH59388] Funding Source: Medline
- PHS HHS [37919] Funding Source: Medline
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Animal behavior is synchronized to the 24-hour light:dark (LD) cycle by regulatory programs that produce circadian fluctuations in gene expression throughout the body. In mammals, the transcription factor CLOCK controls circadian oscillation in the suprachiasmatic nucleus of the brain; its paralog, neuronal PAS domain protein 2 (NPAS2), performs a similar function in other forebrain sites. To investigate the role of NPAS2 in behavioral manifestations of circadian rhythm, we studied locomotor activity, sleep patterns, and adaptability to both light- and restricted food-driven entrainment in NPAS2-deficient mice. Our results indicate that NPAS2 plays a substantive role in maintaining circadian behaviors in normal LD and feeding conditions and that NPAS2 is critical for adaptability to food restriction.
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