Journal
SCIENCE
Volume 301, Issue 5631, Pages 336-338Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1085242
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Funding
- NIAID NIH HHS [AI43288] Funding Source: Medline
- NIGMS NIH HHS [GM34028] Funding Source: Medline
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Small RNAs, including microRNAs (miRNAs) and short interfering RNAs (siRNAs), are key components of an evolutionarily conserved system of RNA-based gene regulation in eukaryotes. They are involved in many molecular interactions, including defense against viruses and regulation of gene expression during development. miRNAs interfere with expression of messenger RNAs encoding factors that control developmental timing, stem cell maintenance, and other developmental and physiological processes in plants and animals. miRNAs are negative regulators that function as specificity determinants, or guides, within complexes that inhibit protein synthesis (animals) or promote degradation (plants) of mRNA targets.
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