Journal
APPLIED PHYSICS LETTERS
Volume 83, Issue 3, Pages 575-577Publisher
AMER INST PHYSICS
DOI: 10.1063/1.1594830
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We present depth-resolved coherence-domain images of living tissue using a dynamic holographic semiconductor film. An AlGaAs photorefractive quantum-well device is used in an adaptive interferometer that records coherent backscattered (image-bearing) light from inside rat osteogenic sarcoma tumor spheroids up to 1 mm in diameter in vitro. The data consist of sequential holographic image frames at successive depths through the tumor represented as a visual video fly-through. The images from the tumor spheroids reveal heterogeneous structures presumably caused by necrosis and microcalcifications characteristic of human tumors in their early avascular growth. (C) 2003 American Institute of Physics.
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