4.4 Article

Solid-phase synthesis of natural product-like macrocycles by a sequence of Ugi-4CR and SNAr-based cycloetherification

Journal

TETRAHEDRON LETTERS
Volume 44, Issue 30, Pages 5575-5578

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0040-4039(03)01378-9

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An on-resin Ugi four-component reaction followed by an intramolecular nucleophilic aromatic substitution (SNAr) has been developed for the rapid access to biaryl-ether containing macrocycles. (C) 2003 Elsevier Ltd. All rights reserved.

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