Journal
VACCINE
Volume 21, Issue 24, Pages 3389-3392Publisher
ELSEVIER SCI LTD
DOI: 10.1016/S0264-410X(03)00339-6
Keywords
maternal antibodies; infant immunity; vaccine response
Categories
Funding
- NIAID NIH HHS [AI 65316] Funding Source: Medline
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Transplacentally-acquired antibodies are important for protection of infants in the early months of life. Maternal antibodies may dampen the infant's primary antibody response to infection or immunization. Even without a measurable response to the initial antigen exposure, the infant will usually have evidence of priming at the time of repeat exposure. No evidence for the development of fetal tolerance after immunization during pregnancy has occurred subsequently in infants following active vaccination. (C) 2003 Elsevier Science Ltd. All rights reserved.
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