Journal
ARCHIVES OF PHARMACAL RESEARCH
Volume 26, Issue 8, Pages 581-584Publisher
PHARMACEUTICAL SOCIETY KOREA
DOI: 10.1007/BF02976703
Keywords
prenylated flavonoids; allylated chrysin analogues; vinylated chrysin analogues; anti-inflammatory activity; cyclooxygenase-2; PGE(2) production; Stille reaction
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Vinylated and allylated chrysin analogues were prepared as congeners of prenylated flavonoids and evaluated their anti-inflammatory activity. 8-Substituted chrysin analogues were prepared from 2'-hydroxy-3'-iodo-4',6'-dimethoxyacetophenone in 3 steps. 3-Allylated chrysin analogues were prepared from chrysin in 3 steps. Synthesized chrysin analogues (4, 5 and 8) showed moderate inhibitory activities of PGE(2) production from LPS-induced RAW 264.7 cells.
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