Journal
PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS
Volume 69, Issue 2-3, Pages 87-97Publisher
CHURCHILL LIVINGSTONE
DOI: 10.1016/S0952-3278(03)00069-3
Keywords
phospholipase A(2); arachidonic acid; eicosanoids; inflammation; cancer
Funding
- NHLBI NIH HHS [P01 HL36110] Funding Source: Medline
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Considerable progress has been made in characterizing the individual participant enzymes and their relative contributions in the generation of eicosanoids, lipid mediators derived from arachidonic acid, such as prostaglandins and leukotrienes. However, the role of individual phospholipase (PL) A(2) enzymes in providing arachidonic acid to the downstream enzymes for eicosanoid generation in biologic processes has not been fully elucidated. In this review, we will provide an overview of the classification of the families of PLA(2) enzymes, their putative mechanisms of action, and their role(s) in eicosanoid generation and inflammation. (C) 2003 Elsevier Ltd. All rights reserved.
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