Journal
CURRENT OPINION IN IMMUNOLOGY
Volume 15, Issue 4, Pages 450-455Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/S0952-7915(03)00075-X
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Funding
- NHLBI NIH HHS [HL68526, HL71241] Funding Source: Medline
- NIAID NIH HHS [AI50732, AI47485, AI37859] Funding Source: Medline
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Mycobacterium tuberculosis is successful as a pathogen because of its ability to persist in an immunocompetent host. This bacterium lives within the macrophage, a cell whose function is the elimination of microbes. Recent advances have improved our understanding of how M. tuberculosis evades two major antimicrobial mechanisms of macrophages: phagolysosome fusion and the production of toxic reactive nitrogen intermediates. M. tuberculosis also modulates antigen presentation to prevent the detection of infected macrophages by CD4(+) T cells.
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