Journal
NEPHROLOGY DIALYSIS TRANSPLANTATION
Volume 18, Issue -, Pages 8-13Publisher
OXFORD UNIV PRESS
DOI: 10.1093/ndt/gfg1069
Keywords
cell cycle; cyclin; glomerular epithelial cell; kidney; podocyte proliferation
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Funding
- PHS HHS [61-8461, 62-4102, 62-3547, 62-0359] Funding Source: Medline
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Injury to the podocyte underlies many forms of glomerular disease. In contrast to mesangial and endothelial cells, podocytes do not typically proliferate. Moreover, the lack of proliferation is thought to underlie the development of glomerulosclerosis. Studies have recently shown that the lack of podocyte proliferation is due to an increase in cyclin-dependent kinase inhibitors, which arrest the cell cycle. Current work is aimed at further delineating the mechanisms regulating podocyte proliferation.
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