Journal
PARKINSONISM & RELATED DISORDERS
Volume 9, Issue -, Pages S59-S64Publisher
ELSEVIER SCI LTD
DOI: 10.1016/S1353-8020(03)00023-3
Keywords
Parkinson's disease; Lewy bodies; pathogenesis
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Funding
- NIEHS NIH HHS [ES12068] Funding Source: Medline
- NINDS NIH HHS [NS38399] Funding Source: Medline
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Parkinson's disease (PD) is occasionally caused by single gene mutations or by single toxic exposures, but most cases of PD are probably caused by some combination of genetic susceptibility and environmental exposure. Using rotenone as a prototype for an environmental toxicant, we argue here that genetic and environmental causes of PD converge on common pathogenic mechanisms. If so, protective strategies devised for one type of PD may be broadly useful for other forms of the disease. (C) 2003 Published by Elsevier Ltd.
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