Effect of proinflammatory cytokines (IL-6, TNF-α, IL-1β) on hemodynamic performance during orthotopic liver transplantation

Background. Proinflammatory cytokines (IL-6, IL-1beta, TNF-alpha) released during liver transplantation may affect hemodynamic stability. The aim of the present study was to analyze the association between IL-6, TNF-alpha, and IL-1beta and systemic vascular resistance during the phases of liver transplantation. Material and methods. The proinflammatory cytokines IL-6, IL-1beta, and TNF-alpha were analyzed in the blood of 20 consecutive patients who underwent transplantation. Blood samples were drawn from the pulmonary artery at serial times during surgery. Hemodynamic parameters were determined using a cardiac output monitor. Correlations between parameters were analyzed using the Spearman's rho and Kendall's tau-b methods. Results. Both in the vena cava and the pulmonary artery, significant association was observed between basal values of IL-6 during hepatectomy and systemic vascular resistance during the phases of liver transplantation: hepatectomy phase (r = .76, P = .02), anhepatic phase (r = .78, P = .03) and reperfusion phase (r = .87, P = .005). Conclusions. Basal values of IL-6 may be considered a prognostic factor for hemodynamic performance during the phases of liver transplantation.