Journal
BRAIN RESEARCH
Volume 980, Issue 1, Pages 151-155Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0006-8993(03)02923-8
Keywords
signal transducer and activator of transcription; vascular organ of the laminae terminalis; subfornical organ; glia; fever; cytokine
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Pyrogenic treatment with lipopolysaccharide (LPS) or interleukin-6 (IL-6) induces nuclear STAT3 translocation in the vascular organ of the laminae terminalis (OVLT) and the subfornical organ (SFO). STAT3 immunohistochemistry was combined with the detection of marker proteins (glial, neuronal, endothelial) and the nuclear DAPI stain to determine the phenotype of responding cells. At time points with high pyrogen-induced IL-6 plasma levels, nuclear STAT3 signals were co-localized with an astrocytic cell marker. IL-6 might therefore mediate genomic activation of OVLT/SFO astrocytes during LPS-induced fever. (C) 2003 Elsevier B.V. All rights reserved.
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