Journal
CURRENT OPINION IN GENETICS & DEVELOPMENT
Volume 13, Issue 4, Pages 341-350Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/S0959-437X(03)00077-7
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A signaling complex in which atypical protein kinase C associates with a regulatory protein, Par6, plays an essential role in establishing cell polarity. Recent studies in organisms ranging from worms to mammals have highlighted some of the conserved mechanisms by which the assembly, localization and activity of this complex are regulated. Recent work is also beginning to unravel how this complex acts in concert with additional molecular complexes to establish and maintain polarity.
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